S80212 |
Pimasertib (AS-703026) |
源葉(MedMol) | 96% |
- 提示:詳情請下載說明書。
- 產(chǎn)品描述: Pimasertib (AS703026) is a highly selective, ATP non-competitive allosteric orally available MEK1/2 inhibitor
- 靶點: MEK1;MEK2;MEK
- 體內(nèi)研究:
Pimasertib (15, 30 mg/kg) significantly inhibits the growth of tumor in the human H929 MM xenograft model in CB17 SCID mice. Pimasertib (10 mg/kg, p.o.) inhibits tumor growth of cetuximab-resistant tumor attributed by K-ras mutation
- 參考文獻:
1. Kim K, et al. Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo. Br J Haematol, 2010, 149(4), 537-549. 2. Park SJ, et al. The MEK1/2 inhibitor AS703026 circumvents resistance to the BRAF inhibitor PLX4032 in human malignant melanoma cells. Am J Med Sci. 2013 Dec;346(6):494-8. 3. Yoon J, et al. MEK1/2 inhibitors AS703026 and AZD6244 may be potential therapies for KRAS mutated colorectal cancer that is resistant to EGFR monoclonal antibody therapy. Cancer Res, 2011, 71(2), 445-453.
- 溶解性: DMSO : ≥ 100 mg/mL (231.91 mM)
- 保存條件: -20℃
- 配置溶液濃度參考:
1mg 5mg 10mg 1 mM 2.319 ml 11.596 ml 23.191 ml 5 mM 0.464 ml 2.319 ml 4.638 ml 10 mM 0.232 ml 1.16 ml 2.319 ml 50 mM 0.046 ml 0.232 ml 0.464 ml
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輸入產(chǎn)品批號:
本計算器可幫助您計算出特定溶液中溶質的質量、溶液濃度和體積之間的關系,公式為:
質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)