S80346 |
IWP L6 |
源葉(MedMol) | ≥98%(HPLC) |
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- 產(chǎn)品描述: IWP L6 (Porcn Inhibitor III) is a Porcn inhibitor with an EC50 of 0.5 nM.
- 靶點(diǎn): EC50 Value: 0.5 nM;Porcupine
- 體外研究:
IWP-L6 (Porcn Inhibitor III) effectively suppressed the phosphorylation of dishevelled 2 (Dvl2) in HEK293 cells, a biochemical event associated with many Wnt-dependent cellular responses. IWP-L6 inhibits Wnt mediated branching morphogenesis in cultured embryonic kidneys .
- 體內(nèi)研究:
IWP-L6 (Porcn Inhibitor III) is stable in human plasma over 24 h, it was rapidly metabolized in rat plasma (t1/2 = 190 min), murine plasma (t1/2 = 2 min), and the murine liver S9 fractions (t1/2 = 26 min). The major metabolites are the amide cleavage products. Similar species-dependent metabolitic profiles due to the involvement of carboxylesterase (CES) have been reported with other drug candidates. Despite its modest metabolic stability in mouse-derived plasma, IWP-L6 was highly active in zebrafish. IWP-L6 exhibited more potent activity
- 參考文獻(xiàn):
1. Wang, X., et al., The development of highly potent inhibitors for porcupine. J Med Chem, 2013. 56(6): p. 2700-4.
- 溶解性: Soluble in DMSO
- 保存條件: -20°C
- 配置溶液濃度參考:
1mg 5mg 10mg 1 mM 2.116 ml 10.58 ml 21.16 ml 5 mM 0.423 ml 2.116 ml 4.232 ml 10 mM 0.212 ml 1.058 ml 2.116 ml 50 mM 0.042 ml 0.212 ml 0.423 ml
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輸入產(chǎn)品批號(hào):
本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系,公式為:
質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)