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• 產(chǎn)品描述： KPT-276 is an orally bioavailable selective inhibitor of nuclear export (SINE) that irreversibly bind to CRM1 and block the function of CRM1.

• 靶點(diǎn)： CRM1

• 體內(nèi)研究：
  KPT-276 significantly prolongs survival of leukemic mice and reduces leukemic burden in a xenograft AML mouse model. KPT-276 significantly suppresses tumor growth in an MCL-bearing severe combined immunodeficient mouse model without severe toxicity. KPT-276 reduces monoclonal spikes in the Vk*MYC transgenic MM mouse model, and inhibits tumor growth in a xenograft MM mouse model.

• 參考文獻(xiàn)：
  1.Ranganathan P, et al. Blood. 2012, 120(9), 1765-1773. 2.Schmidt J, et al. Leukemia. 2013, 27(12), 2357-2365. 3.Azmi AS, et al. Exp Hematol. 2013, 41(1), 67-78.

• 溶解性： H2O:<1  mg/mL    Ethanol:<1  mg/mL    DMSO:16  mg/mL  (37.5  mM)

• 保存條件： -20℃

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	2.346 ml	11.73 ml	23.46 ml
  5 mM	0.469 ml	2.346 ml	4.692 ml
  10 mM	0.235 ml	1.173 ml	2.346 ml
  50 mM	0.047 ml	0.235 ml	0.469 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

輸入產(chǎn)品批號(hào)：

本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *