S82236 |
DBPR108 |
源葉(MedMol) | 98% |
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- 產(chǎn)品描述: DBPR108 is an orally bioavailable dipeptide-derived DPP4 inhibitor (IC50: 15 nM) and it has no inhibition on DDP8 and DPP9.
- 靶點(diǎn): DPP-4;Proteasome;Proteasome;?DPP-4
- 體外研究:
DBPR108 displays a more than 3000-fold selectivity over DPP8 DPP9, FAP and DPP-II.
- 體內(nèi)研究:
DBPR108 is a potent, selective, long-acting and safe DPP-IV inhibitor as a potential treatment of type 2 diabetes mellitus. The in vivo effects of DBPR108, including inhibition of plasma DPP-IV activity and suppression of blood glucose elevation, were also demonstrated.
- 參考文獻(xiàn):
1. Yeh TK, et al. (2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV. Bioorg Med Chem Lett. 2010 Jun
- 溶解性: soluble in DMSO
- 保存條件: -20℃
- 配置溶液濃度參考:
1mg 5mg 10mg 1 mM 3.083 ml 15.413 ml 30.827 ml 5 mM 0.617 ml 3.083 ml 6.165 ml 10 mM 0.308 ml 1.541 ml 3.083 ml 50 mM 0.062 ml 0.308 ml 0.617 ml
- 注意:部分產(chǎn)品我司僅能提供部分信息,我司不保證所提供信息的權(quán)威性,僅供客戶(hù)參考交流研究之用。
輸入產(chǎn)品批號(hào):
本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系,公式為:
質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)